Adverse drug reactions observed with Anti tubercular drugs used in treatment of Drug resistant tuberculosis
Keywords:
Adverse drug reaction, Multi drug resistant tuberculosis, National Tuberculosis Elimination Programme.Abstract
Background: -Tuberculosis is one of health problem in India. Emergence of MDR-TB had further increased
the disease burden owing to its difficult & longer duration of treatment. Treatment of MDR TB Is associated
with increased incidence of ADR which adversely affects the outcome and compliance. Material & Method:A
retrospective
study
of
MDR
TB
cases
reporting
with
ADR
at
Nodal
DRTB
centre
Jhansi
are
recoded
and
analysed.
Result:-Among
total
of
303
patients
reporting,
most
frequent
ADR
observed
was
Gastro
intestinal
symptoms
(53.79%)
followed
by
dermatological
(18.81%)
and
neurological
symptoms
(18.81%).
ADRs
were
significantly
associated
with
non-compliance
to
treatment
and
default.
Conclusion:-A
proper
counselling
of
the
patient prior to start of therapy must be done .Probable ADR to treatment must be explained such that
early recognition and intervention with minimal or no modification can be done. Early detection and proper
management of ADRs will ensure better compliance and treatment outcome.
